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John Knox was a Scottish cleric, (1513-1572), who died in poverty and largely forgotten. However, he was one of the most important figures in the history of Scotland and he changed that nation and his influence is still felt to this day. He was the leader of the Scottish Reformation and an influential theologian.  Knox was also very important in the politics of the time and he played a pivotal role in the political evolution of Scotland and the British Isles. This article will argue that John Knox overthrew Catholicism in Scotland, helped to establish Presbyterianism, paved the way for the unification of Scotland and England and the emergence of the United Kingdom.