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Rome was in a state of collapse, and the Sack had set the city back by a century. The Pope could no longer afford to pay artists and writers, and they gradually drifted away from the city. The capture of Rome in 1527, ended the Renaissance in Rome which had become one of the last centers of the great cultural flourishing in Italy.<ref>Ruggiero, Guido. <i>[https://www.amazon.com/gp/product/0521719380/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=0521719380&linkCode=as2&tag=dailyh0c-20&linkId=099fc32a1ba347508fdb90b622912ce0 The Renaissance in Italy: A Social and Cultural History of the Rinascimento]</i> (Cambridge University Press, 2015), p. 648 </ref>
The Sack of Rome is often considered the end of the Renaissance. The brutal seizure of the Eternal City and the subsequent eight-month occupation by a band of rebellious soldiers changed the Papacy and Italy. The Papacy was no longer able to resist Spanish domination, and it increasingly followed the policies of first Charles V and later Phillip II. This led to increasing efforts by the Pope, through the Office of the Inquisition to enforce Religious Orthodoxy. The Sack of Rome shattered the city’s economy, and no longer was the Pope’s ability to spend lavishly on buildings, books, and works of art. These factors changed Italian society.